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Assad, Gaddafi, Saddam, Abbas, and etc.

Each was removed for not going along with Israel's agenda.

Though I wonder how much that has changed since Assad is out. He was holding back the Islamic extremists. Now the Druze and the Yezidi are between a rock and a hard place.

USA.

ISIS was definitely supported by intelligence agencies, rich Saudis, etc. But they have attacked Israel. For example:

https://en.wikipedia.org/wiki/June_2017_Jerusalem_attack

This book should be read:

https://z-lib.gs/book/18173338/54a511/isis-a-history-2021-edition.html

But to understand ISIS you don't need a Zionist plot. You need to understand it comes out of the broader Sunni jihadi movement, came out of al Qaeda specifically, but differed with bin Laden's 'far enemy' strategy of prioritizing attacks on the US in favor of a 'near enemy' strategy of overthrowing apostate Arab governments and attacking Shias in Iraq to polarize and carve away the Sunni areas into a caliphate. It worked. They just took on too many people at once. That was their mistake.

The KSA is an apostate regime by any reasonable jihadi estimate. It is aligned with the US, probably has the most evil political elite on earth, provides the US with bases to control the Middle East, and is at best do nothing on the Palestine issue. The posture of ISIS and al Qaeda is armed struggle.

Regarding the whole business - the Gulf states, who are US allies, prefer Sunni jihadis over Shias and Assad. At least if they attack common enemies. Weakening Assad also weakens Iran. That helps Israel for geographical/security reasons. Israel is now worried Syria, Egypt, etc., may gang up on them though. It's a matter of managing enemies.