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Just came to my mind, I was watching before some interviews with Lynch, he knew some interesting things indeed...
And when reading about this Plum Island's Lab 257, I wonder if there was some Lab 253 too.

Lynch is using 253 number a lot, so maybe it's related somehow.

Why I would even think that?

Well, in 'Fire Walk With Me' movie, was this "Let's Rock" sign written on the windshield, but to me looks exactly like an Ebola virus, or Marburg virus even more - but when movie was out back then, I thought maybe it's coincidence, and I'm seeing things which are not there: Here: https://files.catbox.moe/s2i3ky.jpg

Now I think Lynch knew about a thing or two, and maybe that 253 number was indeed a reference to some crazy lab he knew about.

I never heard about any 'Lab 253' before, just of this Lab 257 on this disgusting Plum Island, but who knows. Interesting.