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Yes, virtually every sort of stressful task repeated enough times will result in a repetitive strain injury. There are ways of running that mitigate this to some extent, but especially as you age, there is no avoiding damage from repetitive strain.

The question isn't whether you'll have it, really, it's deciding what kind is worth it to have. If you are one of those freaks of nature who just loves running, then do what you love. But if you don't love it, there are plenty of forms of cardio that are effective and less impactful on your joints.

Weight training is another example. At some point, training is going to result in wear and tear. Some of it is worth it, and if you're smart, you can avoid injury and stay pretty fucking strong (relatively) until the day you croak.

You choose the stresses you accept; you can't avoid them by trying to avoid physical stress altogether, which only results in other forms of physiological stress.

We ain't meant to live forever. Brisk walking and short sprints are both better forms of cardio. I think aging people are much better off focusing on a strength program with some good, long walks throughout the week to minimize soreness from weight training. Just walking for 20 or 30 minutes after a training session at a pace where talking to someone while doing it would be annoying is an excellent way to beat delayed onset soreness and to enhance recovery.

yes, neri, don't run all the time, it's crazy, before you know it you end up in a wheelchair

Yes, it is.
However, your knees have been destroyed by something else.

Probably, but wtf is up with all the runners who go around shitting those little turds?

It destroys your spinal column.

Only if you're a fat fuck.