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Serious complications of ACAM2000 include:
• Myocarditis (inflammation of the heart muscle) and pericarditis (inflammation of the lining
outside the heart). Most cases have occurred within 1-2 weeks after vaccination. Symptoms of
myocarditis and pericarditis include:
o Chest pain
o Shortness of breath or difficulty breathing
o Feelings of having a fast-beating, fluttering, or pounding heart
Symptoms of myocarditis and pericarditis may be different in children and may also include:
o Fainting
o Unusual and persistent irritability
o Unusual and persistent poor feeding
o Unusual and persistent fatigue or lack of energy
o Persistent vomiting
o Persistent pain in the abdomen
o Unusual and persistent cool, pale skin
• Inflammation of the brain or spinal cord
• Serious skin infections such as a rash caused by widespread infection of the skin (known as
eczema vaccinatum), buildup of inflamed tissue around the vaccination site that may at first
look like a bullseye and will grow into a large, non-healing sore (known as progressive
vaccinia).
• Spreading of the vaccine virus through the blood to other parts of your body
• Fetal death
• Accidental infection of the eye (which may cause swelling of the cornea causing watery painful
eyes and blurred vision, scarring of the cornea, and blindness)
• Severe allergic reaction after vaccination
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The risks for serious vaccine side effects are greater for people who:
• have heart problems or a history of heart problems
• are taking steroid eye drops or ointment
• have a weakened immune system
• have skin problems such as eczema, atopic dermatitis, burns, impetigo, contact dermatitis,
chickenpox, shingles, psoriasis, or uncontrolled acne
• are less than 1 year old
• are pregnant or become pregnant within 6 weeks after vaccination