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Never was that bad for me actually. When you get really good shit the come up is scary though. Your brain thinks that you're dying. Then just pure ecstasy

MDMA comedowns were totally miserable. One of the worst out there in that regard.

What's interesting is that LSD also heavily binds to serotonin receptors, yet it usually has really pleasant come downs. They're often called "afterglows" because it's the polar opposite of a hangover; you feel rejuvinated the day after. Psilocin and its analogues are hit or miss with negative after effects.