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japanese study: take 5 boosters for COnvid and your immune system will be fucked up for life

submitted by dosvydanya_freedomz to Health 8 monthsSep 11, 2023 01:12:25 ago (+17/-1)     (www.ncbi.nlm.nih.gov)

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10469480/

The bivalent mRNA vaccine is recommended to address coronavirus disease variants, with additional doses suggested for high-risk groups. However, the effectiveness, optimal frequency, and number of doses remain uncertain. In this study, we examined the long-term cellular and humoral immune responses following the fifth administration of the mRNA severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine in patients undergoing hemodialysis. To our knowledge, this is the first study to monitor long-term data on humoral and cellular immunity dynamics in high-risk populations after five doses of mRNA vaccination, including the bivalent mRNA vaccine. Whereas most patients maintained humoral immunity throughout the observation period, we observed reduced cellular immune reactivity as measured by the ancestral-strain-stimulated ELISpot assay in a subset of patients. Half of the individuals (50%; 14/28) maintained cellular immunity three months after the fifth dose, despite acquiring humoral immunity. The absence of a relationship between positive controls and T-Spot reactivity suggests that these immune alterations were specific to SARS-CoV-2. In multivariable analysis, participants aged ≥70 years showed a marginally significant lower likelihood of having reactive results. Notably, among the 14 individuals who received heterologous vaccines, 13 successfully acquired cellular immunity, supporting the effectiveness of this administration strategy. These findings provide valuable insights for future vaccination strategies in vulnerable populations. However, further research is needed to evaluate the involvement of immune tolerance and exhaustion through repeated vaccination to optimize immunization strategies.


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[ - ] beanbagWizard 2 points 8 monthsSep 11, 2023 04:21:24 ago (+2/-0)

Whats that? The mRNA jabs have poor health outcomes for recipients? Like all those animal test subjects? No way!

[ - ] boekanier 2 points 8 monthsSep 11, 2023 04:07:50 ago (+2/-0)

this warning falls on deaf ears for people like paul neri

[ - ] paul_neri 0 points 8 monthsSep 11, 2023 06:12:47 ago (+1/-1)

I trust my Government's expert advisers.

[ - ] bobdole9 1 point 8 monthsSep 11, 2023 10:33:45 ago (+1/-0)

Glad the Nips are saying what everyone else is sweeping under the rug.

[ - ] Doglegwarrior 1 point 8 monthsSep 11, 2023 09:57:38 ago (+1/-0)

VAIDS needs to be the common term when some one gets sick with flu like symptoms after getting a vaccine.