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Ive never heard of it used for lyme but I found some blog that was talking about it in combo with fenben.
There may be other critters in your system from the tick bite, like babesia or erlichia which IVM might clobber. I didn’t see data on Ivm inhibition of borrelia anywhere, but its been shown to inhibit Chlamydia which is also a gram negative bug, so perhaps theres potential for borrelia.

I did a bit of research on IVM during covid mania, and I will say that you are in a “experimental” dosage range but there were several studies done on people in this range for as long as 3 months if I recall correctly: 1.5 to 3 mg / kg a week and it sounds like you are at the upper limit.

You say you are skipping every other week to do fenbendazole. I know less about that drug. But you may be overstressing your liver depending on how fenben is metabolized.

IVM is a blood thinner so be aware that increased bleeding is risk especially in conjunction with aspirin and similar.

The other major sources of side effects, interactions are:
1. P- glycoprotein (PgP) aka MDR1 interaction. IVM is a neurotoxin which could cause twitching, extreme sedation, CNS failure at very high doses but and early sign would be pupil dilation. If your pupils are blown, its too much. PgP forms the blood brain barrier which blocks IVM from entering the brain so be aware of drugs that interfere with PgP. Some drugs weaken it.

2. The P-450 liver enzymes. There are a bunch of these enzymes that metabolize different drugs, and many drugs increase or decrease the levels of these enzymes, which create many drug-drug interactions.
IVM is metabolized by CYP3A4, so any drug that increases/decreases that enzyme could cause you to have more/less IVM in your system. Check if fenben or other drugs you take do this. Also IVM suppresses 2C9, 2C19, 2D6, and CYP3A4 so if you take other drugs (like fenben) that are metabolized by these enzymes you could be getting too much of that drug.

Covid19criticalcare.com has a list of drugs with potential interactions somewhere on that site
Remember that the high dose IVM studies were not using other drugs in combination with IVM.

You should take yogurt or probiotic 12 hrs or so after you take the IVM because its wiping out your natural gut biota. It is an antibiotic. Its going to kill a lot of stuff on its way through.

You may know that both these drugs are also used as diy chemotherapy for cancer.

I would advise that you give yourself a break after 3 months or so and listen if your body tells you to stop sooner.

Have you tried azlocillin?

Also have you looked in to senolytic therapy like rapamycin? Senolytics can potentially improve a lot of chronic conditions by helping to kill off damaged and dysfunctional cells. It occurs to me that some of the problems of chronic lyme may be due to some damaged cells that can be eliminated. You could look for an anti-aging doc with experience of senolytics.

Good gravy that is a LOT of ivermectin. 12 mg per adult, 2 days in a row is fine (in my experience). But you do you.

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Why would i take ivermectin if i am not sick?