Im trying to understand what geert vanden bossche is saying about the evolution of this virus. Broadly I understand that the vaccine let to mutations on the RBD which made the vaccine neutralizing antibodies less effective and additionally encouraged mutations which increased infectivity such as a change in electrical charge on the spike which helps it compromise the ACE2 receptor more readily.
On top of that, vaccinated people may have higher viral loads while remaining asymptomatic. Vaccinated people may be superspreaders. Some of this may be due to ADE type phenomenon. Vanden Bossche talks about different kinds of infections and a lot of complicated interplay among different types of antibodies etc. I’ll let you guys know whet I get a handle on this shit. He seems to think herd immunity through natural infection is the only way forward.
It may be related to a phenomenon called vaerd, vaccine-associated enhanced respiratory disease. It's the exact thing that happened when they attempted to vaccinate people for sars-cov and mers. It made people more susceptible to respatory illnesses, I'm bullshitting if I attempt to explain why or how this works but it something I was made aware of and have been watching for.
Thank you for the bread crumb. I think I have a handle on the ADE mechanism which promotes infection of monocytes through the Fc receptor by the antibodies. But some of these guys seem to be refering to other types of immunity mediated enhancement mechanisms and Im foggy on how they might work. I have seen a lot of mention of eosinophilic infiltrates as a marker for enhanced infection and I believe thats why many of these dudes are calling for more autopsies.
[ + ] 1Icemonkey
[ - ] 1Icemonkey 1 point 3.7 yearsOct 11, 2021 14:01:59 ago (+1/-0)
[ + ] PostWallHelena
[ - ] PostWallHelena 1 point 3.7 yearsOct 11, 2021 14:26:50 ago (+1/-0)
[ + ] PostWallHelena
[ - ] PostWallHelena 1 point 3.7 yearsOct 11, 2021 14:37:54 ago (+1/-0)*
On top of that, vaccinated people may have higher viral loads while remaining asymptomatic. Vaccinated people may be superspreaders. Some of this may be due to ADE type phenomenon. Vanden Bossche talks about different kinds of infections and a lot of complicated interplay among different types of antibodies etc. I’ll let you guys know whet I get a handle on this shit. He seems to think herd immunity through natural infection is the only way forward.
[ + ] Lostandfound
[ - ] Lostandfound 1 point 3.7 yearsOct 11, 2021 18:05:23 ago (+1/-0)
[ + ] PostWallHelena
[ - ] PostWallHelena 2 points 3.7 yearsOct 11, 2021 18:21:12 ago (+2/-0)