All mice exhibited histopathologic changes in lungs two days after challenge including all animals vaccinated (Balb/C and C57BL/6) or given live virus, influenza vaccine, or PBS suggesting infection occurred in all. Histopathology seen in animals given one of the SARS-CoV vaccines was uniformly a Th2-type immunopathology with prominent eosinophil infiltration, confirmed with special eosinophil stains.
Can someone translate this excerpt from the conclusion into layman's terms:
In contrast to our results, those studies did not find clear evidence of the Th2 type immunopathology on challenge of mice given a vector vaccine for the S protein. The finding of a Th-2-type pathology in our studies in animals immunized with an rDNA-produced S protein is unequivocal.
[ + ] Prairie
[ - ] Prairie 1 point 3.9 yearsAug 11, 2021 16:15:11 ago (+1/-0)
[ + ] ymihere
[ - ] ymihere [op] 0 points 3.9 yearsAug 11, 2021 23:17:36 ago (+0/-0)
[ + ] Nagasaki
[ - ] Nagasaki 0 points 3.9 yearsAug 12, 2021 01:42:06 ago (+0/-0)
[ + ] CoinQuest
[ - ] CoinQuest 0 points 3.9 yearsAug 12, 2021 10:13:00 ago (+0/-0)
Immunopathology is one's immune system reaction.
https://mpkb.org/home/mp/immunopathology
Th2 is one of two types of immune responses generated by T helper cells. Both immune responses are mediated by cytokines.
https://pediaa.com/what-is-the-difference-between-th1-and-th2-immune-response/
unequivocal: in a way that is clear and unambiguous
So: We studied mice injected with a spike protein forming vaccine. It was clear and unambiguous that they had imune responses in their lungs.
[ + ] Nagasaki
[ - ] Nagasaki 0 points 3.8 yearsAug 14, 2021 09:01:22 ago (+0/-0)