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"Don't worry guys, mRNA can't change your DNA!" -- New Discovery Shows Human Cells Can Write RNA Sequences Into DNA

submitted by GloryBeckons to Covid1984 3.8 yearsJul 29, 2021 12:45:25 ago (+35/-3)     (scitechdaily.com)

https://scitechdaily.com/new-discovery-shows-human-cells-can-write-rna-sequences-into-dna-challenges-central-principle-in-biology/

Remember how they "fact checked" and sold the vaccines as being completely safe, and totally not gene modification, because all the mRNA just disappears after a while, and there's no way it could possibly change your DNA in a permanent way?

Oops.

> In a discovery that challenges long-held dogma in biology, researchers show that mammalian cells can convert RNA sequences back into DNA

> Cells contain machinery that duplicates DNA into a new set that goes into a newly formed cell. That same class of machines, called polymerases, also build RNA messages, which are like notes copied from the central DNA repository of recipes, so they can be read more efficiently into proteins. But polymerases were thought to only work in one direction DNA into DNA or RNA. This prevents RNA messages from being rewritten back into the master recipe book of genomic DNA. Now, Thomas Jefferson University researchers provide the first evidence that RNA segments can be written back into DNA, which potentially challenges the central dogma in biology and could have wide implications affecting many fields of biology.

> “This work opens the door to many other studies that will help us understand the significance of having a mechanism for converting RNA messages into DNA in our own cells,” says Richard Pomerantz, PhD, associate professor of biochemistry and molecular biology at Thomas Jefferson University. “The reality that a human polymerase can do this with high efficiency, raises many questions.” For example, this finding suggests that RNA messages can be used as templates for repairing or re-writing genomic DNA.

> The work was published June 11th, 2021, in the journal Science Advances.

Link to actual study (very technical): https://advances.sciencemag.org/content/7/24/eabf1771

Trust the experts, goys. They don't ever get anything wrong. Get your soyience juice jab today.


13 comments block

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[ - ] deleted 0 points 3.8 yearsJul 29, 2021 18:51:38 ago (+1/-1)

deleted

[ - ] GloryBeckons [op] 1 point 3.8 yearsJul 29, 2021 20:01:57 ago (+1/-0)*

this isn't a new discovery, reverse transcriptase has been well known for many decades

Reverse transcriptase is used by viruses. This is a different mechanism, which doesn't involve viruses, and is a new discovery.

it's a huge leap to assume that mRNA will always get converted back into DNA

I made no such claims or assumptions.

I only pointed out that it is possible, in spite of claims that it was not. Not that it always happens.

trying to get us interested in absurd pseudoscience

All I did was quote and link to a scientific study. How is that pseudoscience?

You, meanwhile, provide absolutely nothing to back up your claims.

This RNA is not very stable and will get degraded very quickly, most likely will not integrate into your DNA.

There is absolutely no evidence for that claim. It can and does enter your cells. That's the whole point of it. Otherwise the spike proteins would never be created. If that can happen, then so can this. There is no data on whether or how often this happens. Nobody bothered to look for it, because it was assumed to be impossible.

Even if it does, it only has access to the cells near the injection site in your arm

That is absolutely wrong. The mRNA, in its LNP shells, lasts in our bodies for days. It can and does get into the bloodstream. And it can and does travel all over the body. That's part of the purpose of injecting them into the arm muscle, which has a dense vascular system.

[ - ] Clubberlang 0 points 3.8 yearsJul 29, 2021 21:45:24 ago (+0/-0)

Pretty much at this point if don't believe the opposite of what they tell you. You're lost.

[ - ] mattsixteen24 1 point 3.8 yearsJul 29, 2021 16:59:27 ago (+1/-0)

So maybe in the future all one will need is some gene therapy if they have genetic difficulties?

[ - ] TheYiddler 0 points 3.8 yearsJul 30, 2021 00:38:08 ago (+0/-0)

Not that easy. This can turn some cells into drug factories, but not many get the effect so the underlying problem is likely to persist.

As for that drug factory... dosage is incredibly difficult to control using this method. Thus the huge number of jab side effects.

[ - ] Nosferatjew 2 points 3.8 yearsJul 29, 2021 14:24:10 ago (+2/-0)

This is hardly a new discovery. I learned this in highschool.

[ - ] theBreadSultan 5 points 3.8 yearsJul 29, 2021 17:10:14 ago (+5/-0)

This whole Dna 'fact check' is bullshit to anyone with half a brain.

Ffs. The things that can and do fuck with your dna, is longer than the list of shit that can't.

But now we are suddenly being told that the integrity of our dna is equal to the 2020 us election

[ - ] Mr7Slug 10 points 3.8 yearsJul 29, 2021 13:15:39 ago (+10/-0)

RNA is what literally directs the creation of DNA. To think that mRNA doesnt impact DNA is to have an absolute lack of knowledge on the matter. Or to be a malicious liar.

[ - ] Nosferatjew 5 points 3.8 yearsJul 29, 2021 14:23:39 ago (+5/-0)

I learned exactly this in my highschool biology class.

[ - ] GloryBeckons [op] 6 points 3.8 yearsJul 29, 2021 14:52:01 ago (+6/-0)

I think you guys must be thinking of "complementary DNA" which is not the same as RNA. Or maybe of RNA primers.

During DNA replication, short RNA sequences called primers play a role in getting the replication process started, once the DNA helix has been unzipped into two strands.

However, these RNA primers merely serve as anchor points, and the actual replication occurs by attaching complementary DNA, not RNA, to each strand, resulting in two double-strand DNA helices. The Primers are then stripped out. No RNA is left in the helix at the end of this process, and no DNA in the helix was at any point transcribed from RNA.

It was previously thought mRNA was only ever transcribed from DNA, in order to then produce proteins. This study shows human cells can in fact transcribe messenger RNA back into DNA, and routinely do so. The purpose is unclear. Perhaps it's an error correction mechanism.

[ - ] try 0 points 3.8 yearsJul 29, 2021 15:49:35 ago (+3/-3)

Your words of correction will not sink in to them.

But they might be interested to know that products created by mRNA and even RNA virus can alter human DNA , known long before 2021 :

A retrovirus is a virus that uses RNA as its genetic material. When a retrovirus infects a cell, it makes a DNA copy of its genome that is inserted into the DNA of the host cell.

from

https://www.genome.gov/genetics-glossary/Retrovirus

but the new 2021 paper is novel information because the types of mRNA sequences created by humans never re-enter human DNA, nor do most mRNA.

Gene therapy used to focus on just viral delivery therapies , and now some may start toying with mRNA therapies to cure cystic fibrosis, etc.

[ - ] GloryBeckons [op] 2 points 3.8 yearsJul 29, 2021 15:57:19 ago (+2/-0)

Indeed, it was known that viruses could do this. But not that human cells were capable of doing it on their own.